UNIT
I
1) Atomic structure and valency, Radioactivity, Radio
isotopes and Pharmaceutical applications of Radio Pharmaceuticals.
2) Sources of impurities in Pharmaceutical substances.
3) A systematic study of inorganic compounds for their
preparation, assay and use like oxygen, Sulphur, Halogens,
Nitrogen, Phosphorous, Boron, Calcium, Barium and lead.
UNIT II
1) Official compounds of Sodium, Potassium, Copper,
Silver, Gold, Magnesium, Zinc Mercury, Iron and Aluminum.
2) Methods of preparation and use of Chemical reagents
in Pharmaceutical Analysis.
3) Theory of Co-ordination Compounds with special reference
to application in Pharmaceutical Analysis via EDTA,
Dimercaprol, Pencillamine.
UNIT III
1) Physiochemical properties of gasses, liquids and
solids. Density, Surface tension, Viscosity and physical
properties.
2) Osmosis, osmotic pressure, vapour pressure, Raoult's
law, Ostwalds dilution law, Molecular weight determination
by osmotic pressure.
3) Law of mass action, effect of temperature and pressure
on Chemical equilibrium, Energy of activation.
UNIT IV
1) Gases in liquids, liquids in liquids, partially miscible,
completely miscible and completely immisible liquids.
2) Thermochemistry: Heat of reaction, heat of solution,
heat of formation and heat of neutralization and Hess
law.
3) Phase rule and its application to one component system
hydration and dehydration and effervescence.
4) Theory of catalyst and its application in Pharmacy.
UNIT V 1) Electronic configuration, Chemical bounds
of organic chemistry.
2) General methods of preparation of alkanes, alkenes,
alkynes and dienes.
3) Alicyclic hydrocarbons, ring formation, stability,
Bayer's strain theory and Diel's Alder reaction.
PAPER -II
UNIT
I
1. Aromatic character, concept of resonance, Nucleophilic,
Electrophilic substitution reaction, Elimination reactions.
2. Optical isomerism and Geometrical isomerism.
3. Stereo Chemistry of Diphenyl and Nitrogen compounds.
Skeleton structure of medicinally important compounds
belonging to the above series.
UNIT
II
1. Classification, Chemical structure, Synthesis, assay
and therapeutic uses of organic synthetic drugs like,
Antidepressants, General anesthetics, Sedatives and
hypnotics, Narcotic analgesics, Anti - histaminics,
Antimalarials.
UNIT
III
1. Structural elucidation of natural products - General
methods.
2. Structure, chemistry, methods of estimation, uses
of Alkaloids,Carbohydrates, Vitamins and Proteins.
3. Chemistry, methods of estimation of Steroids, Glycosides
and Antibiotics.
UNIT
IV
1. Study of separations and determination involving
chromatography and electrophoreses techniques.
2. Colorimetry, UV and Visible spectrophotometry: Principle,
Beer Lambert's law, study of the working principle of
one cell and two cell colorimeters.
3. Theory and principles separation techniques involving
Ultra centrifuge, HPLC and Gel filtration.
UNIT
V
1. Conductometric titrations, basic concepts different
types Conductometric titrations, application in pharmaceutical
analysis
2. Assay procedure from IP for Non-aqueous titration,
Redox reaction, diazotization and complexometric methods.
3. A preliminary introductory of NMR, MS, IR spectroscopy.
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