MEDICAL SPECIALITY SUBJECT

 

POST GRADUATE DEGREE STANDARD

PAPER -I CODE:017

UNIT I
Cells and Cellular Components
A. Organisation and Components of excaryatic cells
B. Functional role of sub cellular organelles.
C. Methods of Separation of Sub cellular organelles

UNIT II
Composition, Structure and function of Biomolecules A.
Carbohydrates Monosaccharides,disaccharides,Polysaccharides,Fibres, Amino
sugars and muco polysaccharides.

B.
Lipids Fatty acid,Triacylglycerol,Phospholipids,Cholesterol,Lipoproteins,essential
Fattyacids and their derivatives.

UNIT III
Enzymology
A. Classification, Mechanism of action, enzyme kinetics, factors regulating enzyme action
B. Regulation of enzyme action, enzyme inhibitors
C. Enzymes of clinical importance
D. Isoenzymes,Co-enzymes and Co-factors(metallo enzymes)

UNIT IV
Biological Oxidation
A. Enzymes of oxidation, Components of Electron transport chain
B. Oxidative Phosphorylation
C. Inhibitors of Electron transport chain

UNIT V
Digestion and absorption of Nutrients
Carbohydrates, Proteins and Lipids

UNIT VI
Nutrition
Principles involved - BMR,SDA,RDA etc - Protein energy metabolism & Nutritional disorders

UNIT VII
Vitamins
Fat soluble Vitamins and its Deficiency disorders Water soluable Vitamins,
its co-enzyme functions and Deficiency disorders Vitamins assay.

UNIT VIII
Metabolism and Regulation
A.
Carbohydrate -Glycolysis, TCACycle, HMPshuntUronic acidpathway, Galactose Glycogenmetabolism, Gluconeogenesis, Metabolism of fructose

B.
Diabetes Mellitus-Glycogen Storage Disorders- essential Fructosuria - Fructose intolerance-galactosemia-Lactose intolerance

C.
Lipids-Fattyacid Synthesis and oxidation - Synthesis of TAG, Phospholipids Metabolism of Cholesterol, Lipo Proteins and Glycolipids

D.
Lipid Storage disorders,Refsum Disease,Lipoproteinemia

PAPER - II
UNIT I
Strucutre and Functions of Proteins and Nucleic Acid
Amino Acids, Structure of Protein, Biolgically important Peptides, Phsiological Proteins like Hemoglobin, Structural Protein, Myoglobin, Collagen, Immuno globulins, Glycoprotein and Plasma Proteins.
Nucleic Acids-DNA and RNA-Nucleotide Analogues

UNIT II
Metabolism of Amino Acid
Amino Acid Nitrogen and Urea Synthesis. Fate of Carbon Skeleton of Individual Amino AcidsintoSpecializedProducts - Hemoglobin synthesis and breakdown, bilirubin metabolism - Nucleic acids - Purine and pyramidine - synthesis and breakdown

UNIT III
Disorders associated with regulatory pathway
Inborn errors of metabolism - Proteins - Inborn errors of metabolism associated with individual amino acids - Urea cycle disorders- Nucleic acids-Gout,Lesch-Nyhan syndrome, orotic aciduria and other inherited disorders - Porphyrias
-Hemoglobinopathies and Hyper bilirubinaemias

UNIT IV
Molecular Biology
Genetic code,Replication,Transcription,translation,post translational modification -Regulation of gene expression. - Mutation and repair of DNA damage.
DNA Recombinant Technology - its application,gene therapy and molecular basis of diseases

UNIT V
Water and electrolytes and its associated disorders.

UNIT VI
Acid base balance and its disorders
Principles involved - BMR, SDA, RDA etc - Protein energy metabolism & Nutritional disorders

UNIT VII
Hormones and their related disorders
Mechanism of action - Peptide hormones and Steroid hormones etc

UNIT VIII
Functional tests
Assesment of functions of various organs such as Liver, Kidney, Thyroid,Pancreas,GIT,Parathyroid, adrenals and Pituitary

UNIT IX
Priciples of conventional and spcialized laborotory investigations and Instrumentation

UNIT X
Investigations and Interpretations of results in Health and Disease